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And that will cause harm Those patients will not be as well equipped for discharge They will stay in hospital longer, creating problems for other patients They will lose motivation And it will waste money We simply cannot avoid it! Not discharging patients who no longer need to be detained is wrong, and is causing harm In their concern not to make false negative assessments (that is, wrongly deciding that someone is not dangerous) many risk decision-makers make false positive assessments (that is, erroneous assessments that someone is dangerous) Both false negative and false positive decisions are wrong We see the consequences of false negative decisions more dramatically than we do the consequences of false positive assessments Both kinds of error need to be addressed We cannot avoid errors by failing to take risks.

(2000) have therefore isolated spiggin from stickleback nests and bladders, puri ed it using SDS-PAGE (to give a single band of 203 kDa) (Jakobsson et al, 1999), used the pure protein to induce antibody in rabbits, and nally developed an ELISA assay with this antibody More recently, spiggin induction in caged sticklebacks has been used in the UK to survey for the presence of androgens in estuaries, but little activity has been detected to date (P Matthiessen, pers comm, 2001) The spiggin ELISA is still being tested in the laboratory, but early results indicate that this assay will be a useful androgen biomarker in female stickleback kidneys.

are generally compounded on an actual/actual (or discrete) basis. To adjust Macaulay s duration to allow for discrete compounding, we solve for: Dmod where Dmod Modified duration Dmac Macaulay s duration Y Bond-equivalent yield This measure of duration is known as modified duration and is generally what is used in the marketplace. Hicks s method to calculate duration is consistent with the properties of modified duration. This text uses modified duration. Table 5.2 calculates duration for a five-year Treasury note using Macaulay s methodology. The modified duration of this 5-year security is 4.0503 years. For Treasury bills and Treasury STRIPS, Macaulay s duration is nothing more than time in years from settlement to maturity dates. For coupon securities, Macaulay s duration is the product of cash flows and time divided by cash flows where cash flows are in present value terms. Using the equations and Treasury securities from above, we calculate Macaulay duration values to be: 1-year Treasury bill, 0.9205 7.75% 10-year Treasury note, 7.032 30-year Treasury STRIPS, 29.925 Modified durations on the same three Treasury securities are: Treasury bill, 0.8927 Treasury note, 6.761 Treasury STRIPS, 28.786 The summation of column (D) gives us the value for the numerator of the duration formula, and the summation of column (C) gives us the value for the denominator of the duration formula. Note that the summation of column (C) is also the dirty price of this Treasury note. Dmac 833.5384/98.9690 8.4222 in half years 8.4222/2 4.2111 in years Dmac 11 Y>22

To produce an apparently excellent record a hospital, or other risk taker, could adopt a very conservative policy It could decide that nobody, or hardly anyone, is to be allowed day release In that way they greatly reduce the likelihood of false negatives, failure to prevent harm But they increase the likelihood of false positives, failure to identify safety A unit s absence, absolute or even relative, of risk errors (false positive) implies risk decision-making that is too conservative The awkward truth is that risk-takers need errors That some assessments were, apparently, wrong for example, patients did not return after day release can be useful information that the service is not being too conservative Of course the errors should be as minimal as possible; they should be in assessing rather than in managing the risk.

possible by major funding from the National Science Foundation (NSF); specifically, LambdaVision is funded by NSF award CNS-0420477 to EVL (see (www.evl.uic.edu/ cavern/lambdavision), and the OptIPuter is funded by NSF cooperative agreement OCI-0225642, to Calit2 at UCSD (see <www.optiputer.net), with EVL being one of the lead partners. EVL also receives funding from the State of Illinois, General Motors Research, the Office of Naval Research on behalf of the Technology Research, Education, and Commercialization Center (TRECC), and Pacific Interface Inc. on behalf of NTT Optical Network Systems Laboratory in Japan.